Reaction Details | |||
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Target | Methionine aminopeptidase 2 | ||
Ligand | BDBM17416 | ||
Substrate/Competitor | BDBM17353 | ||
Meas. Tech. | Enzyme Inhibition Assay | ||
Ki | 0.5±n/a nM | ||
Citation | Marino, JP; Fisher, PW; Hofmann, GA; Kirkpatrick, RB; Janson, CA; Johnson, RK; Ma, C; Mattern, M; Meek, TD; Ryan, MD; Schulz, C; Smith, WW; Tew, DG; Tomazek, TA; Veber, DF; Xiong, WC; Yamamoto, Y; Yamashita, K; Yang, G; Thompson, SK Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem50:3777-85 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Methionine aminopeptidase 2 | |||
Name: | Methionine aminopeptidase 2 | ||
Synonyms: | Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67 | ||
Type: | Enzyme | ||
Mol. Mass.: | 52884.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P50579 | ||
Residue: | 478 | ||
Sequence: |
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BDBM17416 | |||
BDBM17353 | |||
Name | BDBM17416 | ||
Synonyms: | 1,2,4-Triazole Compound, 74 | methyl 4-({5-[(3-methylbut-2-en-1-yl)sulfanyl]-4H-1,2,4-triazol-3-yl}amino)benzoate | ||
Type | Small organic molecule | ||
Emp. Form. | C15H18N4O2S | ||
Mol. Mass. | 318.394 | ||
SMILES | COC(=O)c1ccc(Nc2nnc(SCC=C(C)C)[nH]2)cc1 |(-10.52,10.03,;-9.75,8.7,;-8.21,8.7,;-7.44,10.03,;-7.44,7.37,;-8.21,6.03,;-7.44,4.7,;-5.9,4.7,;-4.75,3.67,;-3.29,4.15,;-2.81,5.61,;-1.27,5.61,;-.8,4.15,;.67,3.67,;1.81,4.7,;3.28,4.22,;4.42,5.25,;5.89,4.78,;4.1,6.76,;-2.04,3.24,;-5.13,6.03,;-5.9,7.37,)| | ||
Structure |