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TargetMethionine aminopeptidase 2
LigandBDBM17430
Substrate/CompetitorBDBM17353
Meas. Tech.Enzyme Inhibition Assay
Ki 0.3±n/a nM
Citation Marino, JPFisher, PWHofmann, GAKirkpatrick, RBJanson, CAJohnson, RKMa, CMattern, MMeek, TDRyan, MDSchulz, CSmith, WWTew, DGTomazek, TAVeber, DFXiong, WCYamamoto, YYamashita, KYang, GThompson, SK Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem50:3777-85 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Methionine aminopeptidase 2
Name:Methionine aminopeptidase 2
Synonyms:Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:Enzyme
Mol. Mass.:52884.45
Organism:Homo sapiens (Human)
Description:P50579
Residue:478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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  Blast E-value cutoff:
BDBM17430
BDBM17353
NameBDBM17430
Synonyms:1,2,4-Triazole Compound, 88 | N-(5-{[(2-fluorophenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)pyridin-3-amine
TypeSmall organic molecule
Emp. Form.C14H12FN5S
Mol. Mass.301.342
SMILESFc1ccccc1CSc1nnc(Nc2cccnc2)[nH]1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: