| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity nerve growth factor receptor |
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| Ligand | BDBM356098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Functional Activity Assay |
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| IC50 | 0.220±n/a nM |
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| Citation |  Mitchell, H; Fraley, ME; Cooke, AJ; Stump, CA; Chen, Y; Zhang, X; McComas, CC; Schirripa, K; McWherter, M; Mercer, SP; Babaoglu, K; Meng, D; Wu, J; Liu, P; Wood, HB; Bao, J; Li, CS; Mao, Q; Qi, Z TrkA kinase inhibitors, compositions and methods thereof US Patent US9815846 Publication Date 11/14/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity nerve growth factor receptor |
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| Name: | High affinity nerve growth factor receptor |
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| Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA |
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| Type: | n/a |
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| Mol. Mass.: | 87498.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04629 |
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| Residue: | 796 |
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| Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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| BDBM356098 |
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| n/a |
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| Name | BDBM356098 |
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| Synonyms: | N-(6-((2,5-dioxoimidazolidin-1- yl)methyl)-2-phenylpyridin-3- yl)-2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-4- (trifluoromethyl)benzamide | US9815846, Compound 98 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H20F4N6O3 |
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| Mol. Mass. | 552.4797 |
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| SMILES | Cn1ccc(n1)-c1cc(C(=O)Nc2ccc(CN3C(=O)CNC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F |
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| Structure | 
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