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TargetMethionine aminopeptidase 2
LigandBDBM17477
Substrate/CompetitorOctapeptide substrate
Meas. Tech.MetAP2 Enzyme Activity Assay
pH7.4±n/a
Temperature295.15±n/a K
IC50 1400±n/a nM
Citation Sheppard, GS; Wang, J; Kawai, M; Fidanze, SD; BaMaung, NY; Erickson, SA; Barnes, DM; Tedrow, JS; Kolaczkowski, L; Vasudevan, A; Park, DC; Wang, GT; Sanders, WJ; Mantei, RA; Palazzo, F; Tucker-Garcia, L; Lou, P; Zhang, Q; Park, CH; Kim, KH; Petros, A; Olejniczak, E; Nettesheim, D; Hajduk, P; Henkin, J; Lesniewski, R; Davidsen, SK; Bell, RL Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding. J Med Chem49:3832-49 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Methionine aminopeptidase 2
Name:Methionine aminopeptidase 2
Synonyms:Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:Enzyme
Mol. Mass.:52884.45
Organism:Homo sapiens (Human)
Description:P50579
Residue:478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM17477
Octapeptide substrate
Name:Octapeptide substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:819.07
Organism:n/a
Description:n/a
Residue:8
Sequence:
MGKVKVGV