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TargetMethionine aminopeptidase 2
LigandBDBM17478
Substrate/CompetitorOctapeptide substrate
Meas. Tech.MetAP2 Enzyme Activity Assay
pH7.4±n/a
Temperature295.15±n/a K
IC50 9±n/a nM
Citation Kawai, M; BaMaung, NY; Fidanze, SD; Erickson, SA; Tedrow, JS; Sanders, WJ; Vasudevan, A; Park, C; Hutchins, C; Comess, KM; Kalvin, D; Wang, J; Zhang, Q; Lou, P; Tucker-Garcia, L; Bouska, J; Bell, RL; Lesniewski, R; Henkin, J; Sheppard, GS Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett16:3574-7 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Methionine aminopeptidase 2
Name:Methionine aminopeptidase 2
Synonyms:Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:Enzyme
Mol. Mass.:52884.45
Organism:Homo sapiens (Human)
Description:P50579
Residue:478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM17478
Octapeptide substrate
Name:Octapeptide substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:819.07
Organism:n/a
Description:n/a
Residue:8
Sequence:
MGKVKVGV