Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM17648 |
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Substrate/Competitor | BDBM17640 |
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Meas. Tech. | In Vitro Assay for Inhibition of Factor Xa |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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Ki | 2898±1404 nM |
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Citation | Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides. J Med Chem50:1546-57 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM17648 |
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BDBM17640 |
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Name | BDBM17648 |
Synonyms: | 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]thieno[2,3-b]pyridine-2-sulfonamide | N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1k |
Type | Small organic molecule |
Emp. Form. | C18H21ClN4O5S2 |
Mol. Mass. | 472.966 |
SMILES | C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3cc(Cl)cnc3s2)C1=O)C(=O)N1CCOCC1 |r| |
Structure |
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