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TargetApoptosis regulator Bcl-2
LigandBDBM189684
Substrate/Competitorn/a
Meas. Tech.TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay
Ki<0.010±n/a nM
Citation Catron, NLindley, DMiller, JMSchmitt, EATong, P Solid dispersions containing an apoptosis-inducing agent US Patent US10213433 Publication Date 2/26/2019
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM189684
n/a
NameBDBM189684
Synonyms:US10213433, Compound 254 | US11369599, Compound 254 | US9174982, 254
TypeSmall organic molecule
Emp. Form.C48H57ClN8O8S
Mol. Mass.941.533
SMILESCOCCOCCN1CC[C@H](C1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC(C)(C)CC2)c2ccc(Cl)cc2)CC1 |t:54|
Structure
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