Ki Summary

Reaction Details

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Target

Apoptosis regulator Bcl-2

Ligand

BDBM356966

Substrate/Competitor

n/a

Meas. Tech.

TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay

<0.010±n/a nM

Citation

Catron, N; Lindley, D; Miller, JM; Schmitt, EA; Tong, P Solid dispersions containing an apoptosis-inducing agent US Patent US10213433 Publication Date 2/26/2019

More Info.:

Get all data from this article, Assay Method

Apoptosis regulator Bcl-2

Name:

Apoptosis regulator Bcl-2

Synonyms:

Type:

Homodimer or heterodimer

Mol. Mass.:

26269.11

Organism:

Homo sapiens (Human)

Description:

P10415

Residue:

239

Sequence:

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

BDBM356966

n/a

Name

BDBM356966

Synonyms:

N-({5-chloro-6-[(cis-1-fluoro-4-hydroxycyclohexyl)methoxy]pyridin-3-yl}sulfonyl)-4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | US10213433, Compound 350

Type

Small organic molecule

Emp. Form.

C45H49Cl2FN6O6S

Mol. Mass.

891.877

SMILES

CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3cnc(OC[C@@]4(F)CC[C@H](O)CC4)c(Cl)c3)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |wU:33.34,29.30,wD:29.29,c:57,(2.25,14.04,;1.48,12.71,;3.02,12.71,;1.48,11.17,;.15,10.39,;-1.18,11.17,;-2.52,10.39,;-2.52,8.86,;-3.85,8.08,;-3.85,6.55,;-2.52,5.78,;-1.18,6.55,;-1.18,8.08,;-2.52,4.23,;-3.85,3.46,;-3.85,1.93,;-2.52,1.16,;-2.52,-.38,;-3.85,-1.16,;-1.18,-1.16,;-1.18,-2.7,;-2.72,-2.7,;.36,-2.7,;-1.18,-4.23,;-2.52,-5,;-2.52,-6.55,;-1.18,-7.32,;-1.18,-8.86,;-2.52,-9.63,;-2.52,-11.17,;-1.18,-10.39,;-3.85,-11.93,;-3.85,-13.48,;-2.52,-14.24,;-2.52,-15.79,;-1.18,-13.48,;-1.18,-11.93,;.15,-6.55,;1.48,-7.32,;.15,-5,;-1.18,1.93,;.15,1.16,;1.48,1.93,;1.48,3.46,;2.82,4.23,;4.15,3.46,;5.61,3.94,;6.52,2.7,;5.61,1.45,;4.15,1.93,;2.82,1.16,;-1.18,3.46,;-1.18,12.71,;.15,13.48,;-2.52,13.48,;-3.85,12.71,;-5.19,13.48,;-5.19,15.01,;-6.52,15.79,;-3.85,15.79,;-2.52,15.01,)|

Structure