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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Amine oxidase [flavin-containing] B | ||
| Ligand | BDBM356626 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assays-Inhibition of LSD1 | ||
| IC50 | 2500±n/a nM | ||
| Citation |  Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US10214477 Publication Date 2/26/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Amine oxidase [flavin-containing] B | |||
| Name: | Amine oxidase [flavin-containing] B | ||
| Synonyms: | AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) | ||
| Type: | Protein | ||
| Mol. Mass.: | 58768.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27338 | ||
| Residue: | 520 | ||
| Sequence: |
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| BDBM356626 | |||
| n/a | |||
| Name | BDBM356626 | ||
| Synonyms: | US10214477, Example 12 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H26F3N3O2 | ||
| Mol. Mass. | 433.4666 | ||
| SMILES | NC(=O)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(OCc2cccc(c2)C(F)(F)F)nc1 |r,wU:12.14,wD:10.10,(10.21,3.85,;8.88,4.62,;8.88,6.16,;7.54,3.85,;7.54,2.31,;6.21,1.54,;4.87,2.31,;4.87,3.85,;6.21,4.62,;3.54,1.54,;2.21,2.31,;1.44,3.64,;.67,2.31,;-.67,1.54,;-2,2.31,;-3.33,1.54,;-3.33,,;-4.67,-.77,;-6,,;-7.34,-.77,;-8.67,,;-10,-.77,;-10,-2.31,;-8.67,-3.14,;-7.34,-2.31,;-8.67,-4.68,;-8.67,-6.22,;-10.21,-4.68,;-7.13,-4.68,;-2,-.77,;-.67,,)| | ||
| Structure | 
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