Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Lysine-specific histone demethylase 1A | ||
Ligand | BDBM356626 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assays-Inhibition of LSD1 | ||
IC50 | 91.0±n/a nM | ||
Citation | Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US10214477 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysine-specific histone demethylase 1A | |||
Name: | Lysine-specific histone demethylase 1A | ||
Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 92901.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O60341 | ||
Residue: | 852 | ||
Sequence: |
| ||
BDBM356626 | |||
n/a | |||
Name | BDBM356626 | ||
Synonyms: | US10214477, Example 12 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H26F3N3O2 | ||
Mol. Mass. | 433.4666 | ||
SMILES | NC(=O)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(OCc2cccc(c2)C(F)(F)F)nc1 |r,wU:12.14,wD:10.10,(10.21,3.85,;8.88,4.62,;8.88,6.16,;7.54,3.85,;7.54,2.31,;6.21,1.54,;4.87,2.31,;4.87,3.85,;6.21,4.62,;3.54,1.54,;2.21,2.31,;1.44,3.64,;.67,2.31,;-.67,1.54,;-2,2.31,;-3.33,1.54,;-3.33,,;-4.67,-.77,;-6,,;-7.34,-.77,;-8.67,,;-10,-.77,;-10,-2.31,;-8.67,-3.14,;-7.34,-2.31,;-8.67,-4.68,;-8.67,-6.22,;-10.21,-4.68,;-7.13,-4.68,;-2,-.77,;-.67,,)| | ||
Structure |