| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor [538-678,753-922] |
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| Ligand | BDBM17015 |
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| Substrate/Competitor | cFMS -Tie-2 Chimera |
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| Meas. Tech. | cFMs Autophosphorylation Fluorescence Polarization End Point Assay. |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 1300±200 nM |
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| Citation |  Schalk-Hihi, C; Ma, HC; Struble, GT; Bayoumy, S; Williams, R; Devine, E; Petrounia, IP; Mezzasalma, T; Zeng, L; Schubert, C; Grasberger, B; Springer, BA; Deckman, IC Protein engineering of the colony-stimulating factor-1 receptor kinase domain for structural studies. J Biol Chem282:4085-93 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Macrophage colony-stimulating factor 1 receptor [538-678,753-922] |
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| Name: | Macrophage colony-stimulating factor 1 receptor [538-678,753-922] |
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| Synonyms: | 6His.FMS.538-922(TIE2) | CSF1R | CSF1R_HUMAN | FMS | Tyrosine Kinase CSF1-R Mutant (Tie2 KID Chimera) | cFMS -Tie-2 Chimera |
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| Type: | Other Protein Type |
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| Mol. Mass.: | 37574.75 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant protein contains FMS cytoplasmic domain (FMS538-922.6His), in which FMS KID was replaced with Tie-2 KID. |
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| Residue: | 333 |
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| Sequence: | GVDYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG
KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT
HGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTASTRDLLHFSSQVAQGMAFL
ASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD
CVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM
QACWALEPTHRPTFQQICSFLQEQAQEDRRERD
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| BDBM17015 |
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| cFMS -Tie-2 Chimera |
|---|
| Name: | Macrophage colony-stimulating factor 1 receptor [538-678,753-922] |
|---|
| Synonyms: | 6His.FMS.538-922(TIE2) | CSF1R | CSF1R_HUMAN | FMS | Tyrosine Kinase CSF1-R Mutant (Tie2 KID Chimera) | cFMS -Tie-2 Chimera |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 37574.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant protein contains FMS cytoplasmic domain (FMS538-922.6His), in which FMS KID was replaced with Tie-2 KID. |
|---|
| Residue: | 333 |
|---|
| Sequence: | GVDYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFG
KVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT
HGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTASTRDLLHFSSQVAQGMAFL
ASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD
CVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM
QACWALEPTHRPTFQQICSFLQEQAQEDRRERD
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