| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 [44-750] |
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| Ligand | BDBM17659 |
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| Substrate/Competitor | BDBM17658 |
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| Meas. Tech. | Microplate GCPII Radioactivity-Based Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 0.3±0.05 nM |
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| Citation |  Majer, P; Hin, B; Stoermer, D; Adams, J; Xu, W; Duvall, BR; Delahanty, G; Liu, Q; Stathis, MJ; Wozniak, KM; Slusher, BS; Tsukamoto, T Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem49:2876-85 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Glutamate carboxypeptidase 2 [44-750] |
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| Name: | Glutamate carboxypeptidase 2 [44-750] |
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| Synonyms: | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate Carboxypeptidase II (GCPII) | Glutamate carboxypeptidase 2 | Membrane glutamate carboxypeptidase | NAALAD1 | PSM | PSMA | Prostate-specific membrane antigen | Prostate-specific membrane antigen (PSMA) | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
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| Type: | Enzyme |
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| Mol. Mass.: | 79524.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The extracellular domain of human glutamate carboxypeptidase II (rhGCPII, amino acids 44-750) was overexpressed in Drosophila Schneider S2 cells and purified to homogeneity. |
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| Residue: | 707 |
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| Sequence: | KSSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEF
GLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSA
FSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAK
GVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGI
AEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVK
MHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFG
TLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLR
VDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEV
FFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGM
VFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIA
SKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGE
SFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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| BDBM17659 |
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| BDBM17658 |
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| Name | BDBM17659 |
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| Synonyms: | (R,S)-2-phosphonomethylpentanedioic acid | 2-(phosphonomethyl)pentanedioic acid | 2-PMPA | CHEMBL47009 | US10894807, ID P009 | pentanedioic acid analogue, (RS)-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H11O7P |
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| Mol. Mass. | 226.1211 |
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| SMILES | OC(=O)CCC(CP(O)(O)=O)C(O)=O |
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| Structure | 
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