| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM357075 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kallikrein Assay |
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| Ki | 1.43±n/a nM |
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| Citation |  Xu, J; Ali, A; Zhou, W; Gao, Y; Edmondson, SD; Mertz, E; Neelamkavil, SF; Liu, W; Sun, W; Shen, D; Harper, B; Zhu, C; Bara, T; Lim, Y; Yang, M Factor XIA inhibitors US Patent US10214512 Publication Date 2/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM357075 |
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| n/a |
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| Name | BDBM357075 |
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| Synonyms: | 5-(5-chloro-2-(1h-tetrazol-1-yl)phenyl)-2-(15-fluoro-24-((methoxycarbonyl)amino)-4-oxo-3-aza-1(1,3),2(1,2) -dinenzenacyclononaphane-9-yl)pyridine 1-oxide | US10214512, Example 52 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H27ClFN7O4 |
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| Mol. Mass. | 628.053 |
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| SMILES | COC(=O)Nc1ccc-2c(NC(=O)CCCCC(c3cc(F)cc-2c3)c2ccc(c[n+]2[O-])-c2cc(Cl)ccc2-n2cnnn2)c1 |
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| Structure | 
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