| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM17847 |
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| Substrate/Competitor | BDBM17848 |
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| Meas. Tech. | MetAP Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 1500±200 nM |
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| Citation |  Hu, X; Addlagatta, A; Lu, J; Matthews, BW; Liu, JO Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A103:18148-53 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43220.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
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| Residue: | 386 |
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| Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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| BDBM17847 |
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| BDBM17848 |
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| Name | BDBM17847 |
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| Synonyms: | CHEMBL327579 | pyridine-2-carboxylic acid inhibitor, 1 | tert-butyl N-[2-(1,3-thiazol-2-ylcarbamoyl)pyridin-3-yl]carbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N4O3S |
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| Mol. Mass. | 320.367 |
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| SMILES | CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1 |
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| Structure | 
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