Ki Summary

Reaction Details

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Target

Major prion protein

Ligand

BDBM357273

Substrate/Competitor

n/a

Meas. Tech.

Human Platelet Aggregation Inhibition Test

IC50

70.0±n/a nM

Citation

Tran, T; Ibarra, JB; Shin, Y; Ullman, B; Zou, N; Zeng, X Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto US Patent US10214518 Publication Date 2/26/2019

More Info.:

Get all data from this article, Assay Method

Major prion protein

Name:

Major prion protein

Synonyms:

Type:

PROTEIN

Mol. Mass.:

27671.97

Organism:

Homo sapiens (Human)

Description:

ChEMBL_158887

Residue:

253

Sequence:

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG

BDBM357273

n/a

Name

BDBM357273

Synonyms:

2-(((1s,4s)-4-((5-(2- hydroxyethylthio)-3,4- diphenyl-1H-pyrazol-1- yl)methyl)cyclohexyl) methoxy)acetic acid | US10214518, Compound 146

Type

Small organic molecule

Emp. Form.

C27H32N2O4S

Mol. Mass.

480.619

SMILES

OCCSc1c(c(nn1C[C@@H]1CC[C@H](COCC(O)=O)CC1)-c1ccccc1)-c1ccccc1 |r,wU:10.10,13.14,(-2.54,6.04,;-3.63,4.95,;-3.23,3.46,;-4.32,2.37,;-3.92,.89,;-5,-.21,;-4.29,-1.58,;-2.77,-1.32,;-2.54,.2,;-1.21,.97,;.13,.2,;.13,-1.34,;1.46,-2.11,;2.79,-1.34,;4.13,-2.11,;5.46,-1.34,;6.79,-2.11,;8.13,-1.34,;9.46,-2.11,;8.13,.2,;2.79,.2,;1.46,.97,;-4.69,-3.06,;-6.17,-3.46,;-6.57,-4.95,;-5.48,-6.04,;-4,-5.64,;-3.6,-4.15,;-6.49,.19,;-6.89,1.67,;-8.37,2.07,;-9.46,.98,;-9.06,-.5,;-7.58,-.9,)|

Structure