Ki Summary

Reaction Details

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Target

Major prion protein

Ligand

BDBM357274

Substrate/Competitor

n/a

Meas. Tech.

Human Platelet Aggregation Inhibition Test

IC50

220±n/a nM

Citation

Tran, T; Ibarra, JB; Shin, Y; Ullman, B; Zou, N; Zeng, X Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto US Patent US10214518 Publication Date 2/26/2019

More Info.:

Get all data from this article, Assay Method

Major prion protein

Name:

Major prion protein

Synonyms:

Type:

PROTEIN

Mol. Mass.:

27671.97

Organism:

Homo sapiens (Human)

Description:

ChEMBL_158887

Residue:

253

Sequence:

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG

BDBM357274

n/a

Name

BDBM357274

Synonyms:

2-(((1s,4s)-4-((4-(5- fluoropyridin-3-yl)-5- (methylthio)-3-phenyl-1H- pyrazol-1- yl)methyl)cyclohexyl) methoxy)acetic acid | US10214518, Compound 135

Type

Small organic molecule

Emp. Form.

C25H28FN3O3S

Mol. Mass.

469.572

SMILES

CSc1c(c(nn1C[C@@H]1CC[C@H](COCC(O)=O)CC1)-c1ccccc1)-c1cncc(F)c1 |r,wU:8.8,11.12,(-2.88,4.75,;-3.97,3.66,;-3.57,2.18,;-4.65,1.08,;-3.94,-.29,;-2.42,-.04,;-2.2,1.49,;-.86,2.26,;.47,1.49,;.47,-.05,;1.8,-.82,;3.14,-.05,;4.47,-.82,;5.81,-.05,;7.14,-.82,;8.47,-.05,;9.81,-.82,;8.47,1.49,;3.14,1.49,;1.8,2.26,;-4.34,-1.78,;-5.83,-2.18,;-6.23,-3.66,;-5.14,-4.75,;-3.65,-4.35,;-3.25,-2.87,;-6.14,1.48,;-6.54,2.96,;-8.03,3.36,;-9.12,2.27,;-8.72,.79,;-9.81,-.3,;-7.23,.39,)|

Structure