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Reaction Details
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TargetDihydrofolate reductase
LigandBDBM18069
Substrate/CompetitorBDBM18044
Meas. Tech.Enzyme Inhibition Assay
pH7±n/a
Temperature303.15±n/a K
Ki 240±n/a nM
IC50 3000±500 nM
CommentsMIC=0.06 ug/mL.
Citation MUKHIJA, SBANDERA, MPARISI, SRIGO, SLIEB, SLOCIURO, SGILLESSEN, DISLAM, K AR-709-An Investigational diaminopyrimidine: Inhibition, Binding and Mode of Action. Interscience Conference on Antimicrobial Agents in Chemotherapy0:1-1 (2006)  
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_STRPN | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase | dfr | dhfR
Type:Enzyme
Mol. Mass.:19700.70
Organism:Streptococcus pneumoniae
Description:n/a
Residue:168
Sequence:
MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPK
RETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTH
IHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV
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BDBM18069
BDBM18044
NameBDBM18069
Synonyms:5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine | CHEMBL22 | TMP | Trimethoprim | Trimethoprim (TMP) | US10870625, Compound TMP
TypeSmall organic molecule
Emp. Form.C14H18N4O3
Mol. Mass.290.3177
SMILESCOc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Structure
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