Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
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Ligand | BDBM18069 |
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Substrate/Competitor | BDBM18044 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 7±n/a |
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Temperature | 303.15±n/a K |
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Ki | 240±n/a nM |
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IC50 | 3000±500 nM |
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Comments | MIC=0.06 ug/mL. |
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Citation | MUKHIJA, S; BANDERA, M; PARISI, S; RIGO, S; LIEB, S; LOCIURO, S; GILLESSEN, D; ISLAM, K AR-709-An Investigational diaminopyrimidine: Inhibition, Binding and Mode of Action. Interscience Conference on Antimicrobial Agents in Chemotherapy0:1-1 (2006) |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_STRPN | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase | dfr | dhfR |
Type: | Enzyme |
Mol. Mass.: | 19700.70 |
Organism: | Streptococcus pneumoniae |
Description: | n/a |
Residue: | 168 |
Sequence: | MTKKIVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPK
RETLILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTH
IHARVEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRKEV
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BDBM18069 |
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BDBM18044 |
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Name | BDBM18069 |
Synonyms: | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine | CHEMBL22 | TMP | Trimethoprim | Trimethoprim (TMP) | US10870625, Compound TMP |
Type | Small organic molecule |
Emp. Form. | C14H18N4O3 |
Mol. Mass. | 290.3177 |
SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC |
Structure |
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