Reaction Details | |||
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Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
Ligand | BDBM165924 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | The [3H]-methyllycaconitine binding assay | ||
Ki | 20.0±n/a nM | ||
Citation | Luithle, J; Böβ, F; Erb, C; Hafner, F; Schnizler, K; Flessner, T; Van Kampen, M; Van Der Staay, F 2-heteroaryl carboxamides US Patent US10214524 Publication Date 2/26/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuronal acetylcholine receptor subunit alpha-7 | |||
Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
Type: | Enzyme | ||
Mol. Mass.: | 56502.44 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | Q05941 | ||
Residue: | 502 | ||
Sequence: |
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BDBM165924 | |||
n/a | |||
Name | BDBM165924 | ||
Synonyms: | US10214524, Example 19 | US9067931, 19 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H29N3O2S | ||
Mol. Mass. | 447.592 | ||
SMILES | O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3ccc(cc3)N3CCOCC3)c2s1 |r,wU:3.2,(-2.68,-.16,;-2.68,1.38,;-4.02,2.15,;-5.35,1.38,;-5.35,-.16,;-6.68,-.93,;-8.02,-.16,;-8.02,1.38,;-6.68,2.15,;-5.91,.82,;-7.45,.4,;-1.35,2.15,;-1.19,3.68,;.32,4,;1.09,5.33,;2.63,5.33,;3.4,4,;2.63,2.67,;3.4,1.33,;2.63,,;3.4,-1.33,;4.94,-1.33,;5.71,,;4.94,1.33,;5.71,-2.67,;4.94,-4,;5.71,-5.33,;7.25,-5.33,;8.02,-4,;7.25,-2.67,;1.09,2.67,;.06,1.52,)| | ||
Structure |