Reaction Details |
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Target | Renin |
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Ligand | BDBM18327 |
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Substrate/Competitor | tetradecapeptide substrate, TDP |
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Meas. Tech. | In Vitro Enzyme Inhibition |
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pH | 7.2±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 2±n/a nM |
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Citation | Maibaum, J; Stutz, S; Göschke, R; Rigollier, P; Yamaguchi, Y; Cumin, F; Rahuel, J; Baum, HP; Cohen, NC; Schnell, CR; Fuhrer, W; Gruetter, MG; Schilling, W; Wood, JM Structural Modification of the P2' Position of 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets. J Med Chem50:4832-44 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM18327 |
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tetradecapeptide substrate, TDP |
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Name: | tetradecapeptide substrate, TDP |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 4775.39 |
Organism: | n/a |
Description: | n/a |
Residue: | 42 |
Sequence: | H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH
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