Reaction Details | |||
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Target | Lysosomal acid glucosylceramidase | ||
Ligand | BDBM18435 | ||
Substrate/Competitor | BDBM18429 | ||
Meas. Tech. | GC Enzyme Assay | ||
pH | 5.9±n/a | ||
Temperature | 294.15±n/a K | ||
Ki | 514±n/a nM | ||
IC50 | 1060±n/a nM | ||
Km | 28000±n/a nM | ||
Citation | Zheng, W; Padia, J; Urban, DJ; Jadhav, A; Goker-Alpan, O; Simeonov, A; Goldin, E; Auld, D; LaMarca, ME; Inglese, J; Austin, CP; Sidransky, E Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A104:13192-7 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method | ||
Lysosomal acid glucosylceramidase | |||
Name: | Lysosomal acid glucosylceramidase | ||
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) | ||
Type: | Enzyme | ||
Mol. Mass.: | 59724.64 | ||
Organism: | Homo sapiens (Human) | ||
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. | ||
Residue: | 536 | ||
Sequence: |
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BDBM18435 | |||
BDBM18429 | |||
Name | BDBM18435 | ||
Synonyms: | Aminoquinoline compound, 20 | N-[2-(diethylamino)-4-methylquinolin-6-yl]-4-methylcyclohexane-1-carboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C22H31N3O | ||
Mol. Mass. | 353.501 | ||
SMILES | CCN(CC)c1cc(C)c2cc(NC(=O)C3CCC(C)CC3)ccc2n1 |(2.64,-.76,;1.31,.01,;1.31,1.55,;2.64,2.32,;3.98,1.55,;-.02,2.32,;-.02,3.86,;-1.36,4.63,;-1.36,6.17,;-2.69,3.86,;-4.03,4.63,;-5.36,3.86,;-6.69,4.63,;-8.03,3.86,;-8.03,2.32,;-9.36,4.63,;-9.46,6.17,;-10.84,6.85,;-12.12,6,;-13.5,6.68,;-12.02,4.46,;-10.64,3.78,;-5.36,2.32,;-4.03,1.55,;-2.69,2.32,;-1.36,1.55,)| | ||
Structure |