| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
|---|
| Ligand | BDBM359541 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| IC50 | 0.900±n/a nM |
|---|
| Citation |  Lapointe, BT; Fuller, PH; Gunaydin, H; Liu, K; Sciammetta, N; Trotter, BW; Zhang, H; Barr, KJ; Maclean, JK; Molinari, DF; Simov, V Substituted pyrazole compounds as RORgammaT inhibitors and uses thereof US Patent US10221142 Publication Date 3/5/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-gamma |
|---|
| Name: | Nuclear receptor ROR-gamma |
|---|
| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 58218.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51449 |
|---|
| Residue: | 518 |
|---|
| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
|
|
|
|---|
| BDBM359541 |
|---|
| n/a |
|---|
| Name | BDBM359541 |
|---|
| Synonyms: | 4-[(6R or S)-1-({2- chloro-6-[1- (trifluoromethyl)cyclo- propyl]phenyl}car- bonyl)-6-{[(3R)-3- (dimethylamino) pyrrolidin-1- yl]carbonyl}-4,5,6,7- tetrahydro-1H- indazol-3-yl]-3- fluorobenzoic acid | US10221142, Example 21G | US10221142, Example 21H |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H31ClF4N4O4 |
|---|
| Mol. Mass. | 647.06 |
|---|
| SMILES | CN(C)[C@@H]1CCN(C1)C(=O)C1CCc2c(C1)n(nc2-c1ccc(cc1F)C(O)=O)C(=O)c1c(Cl)cccc1C1(CC1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
