Reaction Details |
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Target | Androgen receptor |
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Ligand | BDBM18685 |
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Substrate/Competitor | BDBM26258 |
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Meas. Tech. | Competitive Radioligand Displacement Assay and AR-Mediated Transcription Activation Assay |
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pH | 7.4±n/a |
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Temperature | 277.15±n/a K |
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Ki | 1.65±0.1 nM |
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EC50 | 100±n/a nM |
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Comments | Maximal percentage of transcriptional activation observed is 97.5 +/- 21.6 % |
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Citation | Dalton, JT; Mukherjee, A; Zhu, Z; Kirkovsky, L; Miller, DD Discovery of nonsteroidal androgens. Biochem Biophys Res Commun244:1-4 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Androgen receptor |
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Name: | Androgen receptor |
Synonyms: | ANDR_RAT | Androgen receptor (AR) | Ar | Estrogen receptor | Nr3c4 | androgen |
Type: | Enzyme |
Mol. Mass.: | 98219.08 |
Organism: | Rattus norvegicus (Rat) |
Description: | P15207 |
Residue: | 902 |
Sequence: | MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQET
SPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAP
GKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQ
QQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSKDSYLGGNSTISDSAKELCKAVS
VSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLAECKGLSLDEGPGKGTE
ETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAYQNRDY
YNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPST
GSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFS
ASEVWYPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQK
TCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLR
KCYEAGMTLGARKLKKLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVL
EAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVI
QYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWL
QITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFY
QLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
TQ
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BDBM18685 |
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BDBM26258 |
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Name | BDBM18685 |
Synonyms: | (2R)-3-{[4-(2-chloroacetamido)phenyl]sulfanyl}-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide | Bicalutamide Analogue, (R)-11 | CHEMBL333745 |
Type | Small organic molecule |
Emp. Form. | C20H17ClF3N3O3S |
Mol. Mass. | 471.88 |
SMILES | C[C@](O)(CSc1ccc(NC(=O)CCl)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F |r| |
Structure |
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