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TargetAndrogen receptor
LigandBDBM18699
Substrate/CompetitorBDBM26258
Meas. Tech.Competitive Radioligand Displacement Assay and AR-Mediated Transcription Activation Assay
pH7.4±n/a
Temperature277.15±n/a K
Ki 0.3±0.12 nM
EC50 500±n/a nM
CommentsMaximal percentage of transcriptional activation observed is 82.9 +/- 14.0 %
Citation Dalton JTMukherjee AZhu ZKirkovsky LMiller DD Discovery of nonsteroidal androgens. Biochem Biophys Res Commun 244:1-4 (1998) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Androgen receptor
Name:Androgen Receptor
Synonyms:Androgen receptor (AR) | Estrogen receptor | androgen
Type:Enzyme
Mol. Mass.:98219.08
Organism:Rattus norvegicus (Rat)
Description:P15207
Residue:902
Sequence:
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQET
SPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAP
GKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQ
QQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSKDSYLGGNSTISDSAKELCKAVS
VSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLAECKGLSLDEGPGKGTE
ETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAYQNRDY
YNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPST
GSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFS
ASEVWYPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQK
TCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLR
KCYEAGMTLGARKLKKLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVL
EAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVI
QYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWL
QITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFY
QLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
TQ
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  Blast E-value cutoff:
BDBM18699
BDBM26258
NameBDBM18699
Synonyms:(2R)-3-bromo-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide | CHEMBL296323 | R-3
TypeSmall organic molecule
Emp. Form.C11H10BrF3N2O4
Mol. Mass.371.107
SMILESC[C@](O)(CBr)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O |r|
Structure
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