Reaction Details |
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Target | Androgen receptor |
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Ligand | BDBM18700 |
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Substrate/Competitor | BDBM26258 |
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Meas. Tech. | Competitive Radioligand Displacement Assay and AR-Mediated Transcription Activation Assay |
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pH | 7.4±n/a |
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Temperature | 277.15±n/a K |
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Ki | 2.79±1.35 nM |
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EC50 | 500±n/a nM |
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Comments | Maximal percentage of transcriptional activation observed is 20.5 +/- 7.57 % |
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Citation | Dalton, JT; Mukherjee, A; Zhu, Z; Kirkovsky, L; Miller, DD Discovery of nonsteroidal androgens. Biochem Biophys Res Commun244:1-4 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Androgen receptor |
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Name: | Androgen receptor |
Synonyms: | ANDR_RAT | Androgen receptor (AR) | Ar | Estrogen receptor | Nr3c4 | androgen |
Type: | Enzyme |
Mol. Mass.: | 98219.08 |
Organism: | Rattus norvegicus (Rat) |
Description: | P15207 |
Residue: | 902 |
Sequence: | MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAASIAPPGACLQQRQET
SPRRRRRQQHPEDGSPQAHIRGTTGYLALEEEQQPSQQQSASEGHPESGCLPEPGAATAP
GKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILSEAGTMQLLQQQQQQQ
QQQQQQQQQQQQQQQEVISEGSSSVRAREATGAPSSSKDSYLGGNSTISDSAKELCKAVS
VSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLAECKGLSLDEGPGKGTE
ETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGAVDEAAAYQNRDY
YNFPLALSGPPHPPPPTHPHARIKLENPSDYGSAWAAAAAQCRYGDLASLHGGSVAGPST
GSPPATASSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLASQEGDFS
ASEVWYPGGVVNRVPYPSPSCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQK
TCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLR
KCYEAGMTLGARKLKKLGNLKLQEEGENSSAGSPTEDPSQKMTVSHIEGYECQPIFLNVL
EAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVI
QYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWL
QITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFY
QLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
TQ
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BDBM18700 |
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BDBM26258 |
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Name | BDBM18700 |
Synonyms: | (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-3-iodo-2-methylpropanamide | R-4 |
Type | Small organic molecule |
Emp. Form. | C12H10F3IN2O2 |
Mol. Mass. | 398.1197 |
SMILES | C[C@](O)(CI)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F |r| |
Structure |
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