| Reaction Details |
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 | Report a problem with these data |
| Target | Glucocorticoid receptor |
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| Ligand | BDBM18721 |
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| Substrate/Competitor | BDBM18207 |
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| Meas. Tech. | Fluorescence Polarization Competitive Binding Assay. |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 84±n/a nM |
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| Citation |  Takahashi, H; Bekkali, Y; Capolino, AJ; Gilmore, T; Goldrick, SE; Kaplita, PV; Liu, L; Nelson, RM; Terenzio, D; Wang, J; Zuvela-Jelaska, L; Proudfoot, J; Nabozny, G; Thomson, D Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists. Bioorg Med Chem Lett17:5091-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Glucocorticoid receptor |
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| Name: | Glucocorticoid receptor |
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| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 85656.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04150 |
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| Residue: | 777 |
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| Sequence: | MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
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| BDBM18721 |
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| BDBM18207 |
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| Name | BDBM18721 |
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| Synonyms: | 6-(5-fluoro-2-methoxyphenyl)-2,2-dimethyl-4-{[(2-phenylethyl)sulfanyl]methyl}-1,2-dihydroquinoline | dihydroquinoline compound, 44 | dihydroquinoline-based ligand, 37 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28FNOS |
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| Mol. Mass. | 433.581 |
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| SMILES | COc1ccc(F)cc1-c1ccc2NC(C)(C)C=C(CSCCc3ccccc3)c2c1 |t:18| |
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| Structure | 
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