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TargetThymidylate synthase
LigandBDBM18770
Substrate/CompetitorBDBM18754
Meas. Tech.Thymidylate Synthase (TS) Assay
Ki 1100±n/a nM
Citation Costi, MPGelain, ABarlocco, DGhelli, SSoragni, FReniero, FRossi, TRuberto, AGuillou, CCavazzuti, ACasolari, CFerrari, S Antibacterial agent discovery using thymidylate synthase biolibrary screening. J Med Chem49:5958-68 (2006) [PubMed]  Article
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Thymidylate synthase
Name:Thymidylate synthase
Synonyms:TS | TSase | TYSY_ECOLI | Thymidylate Synthase (TS) | thyA
Type:Enzyme
Mol. Mass.:30475.81
Organism:Escherichia coli
Description:n/a
Residue:264
Sequence:
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
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BDBM18770
BDBM18754
NameBDBM18770
Synonyms:1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(3-fluoro-4-hydroxyphenyl)-3-oxatricyclo[7.3.1.0^{5,13}]trideca-1(12),5,7,9(13),10-pentaen-2-one | Phenolnaphthalein derivative, 3
TypeSmall organic molecule
Emp. Form.C24H13ClF2O4
Mol. Mass.438.807
SMILESOc1ccc(cc1F)C1(OC(=O)c2cccc3c(Cl)ccc1c23)c1ccc(O)c(F)c1
Structure
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