Reaction Details |
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Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
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Ligand | BDBM18785 |
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Substrate/Competitor | BDBM18044 |
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Meas. Tech. | Inhibitor Screening Using Bacterial System (IC50) and Measurement of Inhibition Constant (Ki) |
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pH | 7±n/a |
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Temperature | 298.15±n/a K |
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Ki | 0.69±0.07 nM |
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IC50 | 2120±580 nM |
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Citation | Bunyarataphan, S; Leartsakulpanich, U; Taweechai, S; Tarnchompoo, B; Kamchonwongpaisan, S; Yuthavong, Y Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays. Antimicrob Agents Chemother50:3631-7 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Bifunctional dihydrofolate reductase-thymidylate synthase |
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Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
Synonyms: | DRTS_PLAVI | Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) | PvDHFR-TS |
Type: | Enzyme |
Mol. Mass.: | 71083.97 |
Organism: | Plasmodium vivax (malaria parasite P. vivax) |
Description: | O02604 |
Residue: | 623 |
Sequence: | MEDLSDVFDIYAICACCKVAPTSEGTKNEPFSPRTFRGLGNKGTLPWKCNSVDMKYFSSV
TTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSSWES
IPKQYKPLPNRINVVLSKTLTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYR
ECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTSVSEVYNSKGTTLDFLVYSKVGG
GVDGGASNGSTATALRRTAMRSTAMRRNVAPRTAAPPMGPHSRANGERAPPRARARRTTP
RQRKTTSCTSALTTKWGRKTRSTCKILKFTTASRLMQHPEYQYLGIIYDIIMNGNKQGDR
TGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWE
ANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVIHLIKN
EPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASY
SIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIED
FTISDFTIENYVHHDKITMEMAA
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BDBM18785 |
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BDBM18044 |
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Name | BDBM18785 |
Synonyms: | 5-(3-chlorophenyl)-6-methylpyrimidine-2,4-diamine | CHEMBL22039 | P38 |
Type | Small organic molecule |
Emp. Form. | C11H11ClN4 |
Mol. Mass. | 234.685 |
SMILES | Cc1nc(N)nc(N)c1-c1cccc(Cl)c1 |
Structure |
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