| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Ligand | BDBM18791 |
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| Substrate/Competitor | BDBM18044 |
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| Meas. Tech. | Inhibitor Screening Using Bacterial System (IC50) and Measurement of Inhibition Constant (Ki) |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 0.53±0.06 nM |
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| IC50 | 800±120 nM |
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| Citation |  Bunyarataphan, S; Leartsakulpanich, U; Taweechai, S; Tarnchompoo, B; Kamchonwongpaisan, S; Yuthavong, Y Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays. Antimicrob Agents Chemother50:3631-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
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| Synonyms: | DRTS_PLAVI | Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) | PvDHFR-TS |
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| Type: | Enzyme |
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| Mol. Mass.: | 71083.97 |
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| Organism: | Plasmodium vivax (malaria parasite P. vivax) |
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| Description: | O02604 |
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| Residue: | 623 |
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| Sequence: | MEDLSDVFDIYAICACCKVAPTSEGTKNEPFSPRTFRGLGNKGTLPWKCNSVDMKYFSSV
TTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSSWES
IPKQYKPLPNRINVVLSKTLTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYR
ECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTSVSEVYNSKGTTLDFLVYSKVGG
GVDGGASNGSTATALRRTAMRSTAMRRNVAPRTAAPPMGPHSRANGERAPPRARARRTTP
RQRKTTSCTSALTTKWGRKTRSTCKILKFTTASRLMQHPEYQYLGIIYDIIMNGNKQGDR
TGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWE
ANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVIHLIKN
EPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASY
SIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIED
FTISDFTIENYVHHDKITMEMAA
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| BDBM18791 |
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| BDBM18044 |
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| Name | BDBM18791 |
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| Synonyms: | 5-phenyl-6-(3-phenylpropyl)pyrimidine-2,4-diamine | CHEMBL22693 | P33 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4 |
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| Mol. Mass. | 304.3889 |
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| SMILES | Nc1nc(N)c(-c2ccccc2)c(CCCc2ccccc2)n1 |
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| Structure | 
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