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TargetThyroid hormone receptor alpha
LigandBDBM18864
Substrate/CompetitorBDBM18860
Meas. Tech.TRalpha-Binding Assay.
pH7±n/a
Temperature277.15±n/a K
IC50 0.041±n/a nM
Citation Ye, LLi, YLMellström, KMellin, CBladh, LGKoehler, KGarg, NGarcia Collazo, AMLitten, CHusman, BPersson, KLjunggren, JGrover, GSleph, PGGeorge, RMalm, J Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1. J Med Chem46:1580-8 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Thyroid hormone receptor alpha
Name:Thyroid hormone receptor alpha
Synonyms:C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1
Type:Receptor
Mol. Mass.:54818.00
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1.
Residue:490
Sequence:
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
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  Blast E-value cutoff:
BDBM18864
BDBM18860
NameBDBM18864
Synonyms:3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid | US10322118, Entry 2 | cid_5804 | triiodothyropropionic acid, 5
TypeSmall organic molecule
Emp. Form.C15H11I3O4
Mol. Mass.635.9589
SMILESOC(=O)CCc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
Structure
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