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TargetThyroid hormone receptor beta
LigandBDBM18867
Substrate/CompetitorBDBM18860
Meas. Tech.TRbeta-Binding Assay and Thyroid Response Element (TRAFbeta1) Reporter Assay.
pH7±n/a
Temperature277.15±n/a K
IC50 0.095±0.04 nM
EC50 0.2±n/a nM
Citation Ye, LLi, YLMellström, KMellin, CBladh, LGKoehler, KGarg, NGarcia Collazo, AMLitten, CHusman, BPersson, KLjunggren, JGrover, GSleph, PGGeorge, RMalm, J Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1. J Med Chem46:1580-8 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Thyroid hormone receptor beta
Name:Thyroid hormone receptor beta
Synonyms:ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:Receptor
Mol. Mass.:52793.62
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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  Blast E-value cutoff:
BDBM18867
BDBM18860
NameBDBM18867
Synonyms:2-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}acetic acid | KB-131092 | dibromo phenylacetic acid, 11a
TypeSmall organic molecule
Emp. Form.C17H16Br2O4
Mol. Mass.444.115
SMILESCC(C)c1cc(Oc2c(Br)cc(CC(O)=O)cc2Br)ccc1O
Structure
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