Reaction Details |
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Target | Thyroid hormone receptor beta |
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Ligand | BDBM18870 |
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Substrate/Competitor | BDBM18860 |
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Meas. Tech. | TRbeta-Binding Assay and Thyroid Response Element (TRAFbeta1) Reporter Assay. |
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pH | 7±n/a |
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Temperature | 277.15±n/a K |
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IC50 | 0.15±0.025 nM |
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EC50 | 0.28±n/a nM |
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Citation | Ye, L; Li, YL; Mellström, K; Mellin, C; Bladh, LG; Koehler, K; Garg, N; Garcia Collazo, AM; Litten, C; Husman, B; Persson, K; Ljunggren, J; Grover, G; Sleph, PG; George, R; Malm, J Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1. J Med Chem46:1580-8 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Thyroid hormone receptor beta |
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Name: | Thyroid hormone receptor beta |
Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
Type: | Receptor |
Mol. Mass.: | 52793.62 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
Residue: | 461 |
Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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BDBM18870 |
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BDBM18860 |
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Name | BDBM18870 |
Synonyms: | 3-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenoxy]phenyl}propanoic acid | dichloro phenylpropionic acid, 17 |
Type | Small organic molecule |
Emp. Form. | C18H18Cl2O4 |
Mol. Mass. | 369.239 |
SMILES | CC(C)c1cc(Oc2c(Cl)cc(CCC(O)=O)cc2Cl)ccc1O |
Structure |
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