Reaction Details |
| Report a problem with these data |
Target | Thyroid hormone receptor beta |
---|
Ligand | BDBM18883 |
---|
Substrate/Competitor | BDBM18860 |
---|
Meas. Tech. | TRbeta-Binding Assay |
---|
pH | 7±n/a |
---|
Temperature | 277.15±n/a K |
---|
IC50 | 910±n/a nM |
---|
Citation | Malm, J; Gordon, S; Brandt, P; Carlsson, B; Agback, P; Bäckbro Saeidi, A; Sandberg, J Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity. Bioorg Med Chem Lett17:2018-21 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Thyroid hormone receptor beta |
---|
Name: | Thyroid hormone receptor beta |
Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
Type: | Receptor |
Mol. Mass.: | 52793.62 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
Residue: | 461 |
Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
|
|
|
BDBM18883 |
---|
BDBM18860 |
---|
Name | BDBM18883 |
Synonyms: | 3,5-dibromo-4-[4-hydroxy-3,5-bis(propan-2-yl)phenoxy]benzoic acid | JMC496635 Compound 3 | thyromimetic, 4 |
Type | Small organic molecule |
Emp. Form. | C19H20Br2O4 |
Mol. Mass. | 472.168 |
SMILES | CC(C)c1cc(Oc2c(Br)cc(cc2Br)C(O)=O)cc(C(C)C)c1O |
Structure |
|