| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
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| Ligand | BDBM18885 |
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| Substrate/Competitor | BDBM18860 |
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| Meas. Tech. | TRbeta-Binding Assay |
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| pH | 7±n/a |
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| Temperature | 277.15±n/a K |
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| IC50 | 20±7 nM |
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| Citation |  Koehler, K; Gordon, S; Brandt, P; Carlsson, B; Bäcksbro-Saeidi, A; Apelqvist, T; Agback, P; Grover, GJ; Nelson, W; Grynfarb, M; Färnegård, M; Rehnmark, S; Malm, J Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem49:6635-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Thyroid hormone receptor beta |
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| Name: | Thyroid hormone receptor beta |
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| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
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| Type: | Receptor |
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| Mol. Mass.: | 52793.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM18885 |
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| BDBM18860 |
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| Name | BDBM18885 |
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| Synonyms: | 2-[4-({4-hydroxy-3-[2-(4-nitrophenyl)ethynyl]-5-(propan-2-yl)phenyl}methyl)-3,5-dimethylphenoxy]acetic acid | CHEMBL109279 | JMC496635 Compound 5 | thyromimetic, 5b |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27NO6 |
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| Mol. Mass. | 473.5171 |
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| SMILES | CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O |
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| Structure | 
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