| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor alpha |
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| Ligand | BDBM18957 |
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| Substrate/Competitor | BDBM18860 |
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| Meas. Tech. | TRalpha-Binding Assay. |
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| pH | 7.6±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | >200000±n/a nM |
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| Citation |  van Beeren, HC; Bakker, O; Wiersinga, WM Structure-function relationship of the inhibition of the 3,5,3'-triiodothyronine binding to the alpha1- and beta1-thyroid hormone receptor by amiodarone analogs. Endocrinology137:2807-14 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Thyroid hormone receptor alpha |
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| Name: | Thyroid hormone receptor alpha |
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| Synonyms: | C-erbA-alpha | EAR-7 | EAR7 | NR1A1 | THA_CHICK | THRA | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor alpha | c-erbA-1 |
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| Type: | Receptor |
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| Mol. Mass.: | 46763.30 |
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| Organism: | Gallus gallus (chicken) |
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| Description: | n/a |
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| Residue: | 408 |
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| Sequence: | MEQKPSTLDPLSEPEDTRWLDGKRKRKSSQCLVKSSMSGYIPSYLDKDEQCVVCGDKATG
YHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDGCCVIDKITRNQCQLCRFKKCISVGMAM
DLVLDDSKRVAKRKLIEENRERRRKEEMIKSLQHRPSPSAEEWELIHVVTEAHRSTNAQG
SHWKQKRKFLPEDIGQSPMASMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSEL
PCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDL
GKSLSAFNLDDTEVALLQAVLLMSSDRTGLICVDKIEKCQETYLLAFEHYINYRKHNIPH
FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV
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| BDBM18957 |
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| BDBM18860 |
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| Name | BDBM18957 |
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| Synonyms: | (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine | AMIODARONE HYDROCHLORIDE | Amiodarone | CHEMBL633 | Cordarone | L 3428 | cid_441325 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29I2NO3 |
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| Mol. Mass. | 645.3116 |
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| SMILES | CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1 |
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| Structure | 
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