| Reaction Details |
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 | Report a problem with these data |
| Target | Peregrin |
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| Ligand | BDBM50157570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Alpha Screen competitive assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 114±61 nM |
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| Comments | extracted |
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| Citation |  Meier, JC; Tallant, C; Fedorov, O; Witwicka, H; Hwang, SY; van Stiphout, RG; Lambert, JP; Rogers, C; Yapp, C; Gerstenberger, BS; Fedele, V; Savitsky, P; Heidenreich, D; Daniels, DL; Owen, DR; Fish, PV; Igoe, NM; Bayle, ED; Haendler, B; Oppermann, UCT; Buffa, F; Brennan, PE; Müller, S; Gingras, AC; Odgren, PR; Birnbaum, MJ; Knapp, S Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation. ACS Chem Biol12:2619-2630 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peregrin |
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| Name: | Peregrin |
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| Synonyms: | BR140 | BRPF1 | BRPF1_HUMAN | Bromodomain and PHD finger-containing protein 1 | Peregrin | Protein Br140 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 137524.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108054 |
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| Residue: | 1214 |
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| Sequence: | MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRK
HKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVS
EDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVV
YRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPI
PQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAV
HQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEV
CFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLY
MKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGKGWSS
EKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRL
HSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLER
ARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLS
EVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVR
LREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHTEDAAEEERLVLLENQKHL
PVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPS
SRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPK
TAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDK
STEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTP
SKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDED
SPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEARE
HLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRS
KVQGEQSSETSDSD
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| BDBM50157570 |
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| n/a |
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| Name | BDBM50157570 |
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| Synonyms: | 4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-methoxybenzenesulfonamide | CHEMBL3752151 | D0O6XT | GTPL8573 | NI 57 | NI-57 | US11773085, Compound B26 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17N3O4S |
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| Mol. Mass. | 383.421 |
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| SMILES | COc1cc(ccc1S(=O)(=O)Nc1ccc2n(C)c(=O)c(C)cc2c1)C#N |
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| Structure | 
|
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