| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM19421 |
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| Substrate/Competitor | BDBM19411 |
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| Meas. Tech. | HDAC Enzyme Activity Assay |
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| pH | 8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 40±n/a nM |
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| Citation |  Moradei, OM; Mallais, TC; Frechette, S; Paquin, I; Tessier, PE; Leit, SM; Fournel, M; Bonfils, C; Trachy-Bourget, MC; Liu, J; Yan, TP; Lu, AH; Rahil, J; Wang, J; Lefebvre, S; Li, Z; Vaisburg, AF; Besterman, JM Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem50:5543-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM19421 |
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| BDBM19411 |
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| Name | BDBM19421 |
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| Synonyms: | 4-{[(3,4-dimethoxyphenyl)amino]methyl}-N-[2-hydroxy-5-(thiophen-2-yl)phenyl]benzamide | benzamide-type inhibitor, 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24N2O4S |
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| Mol. Mass. | 460.545 |
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| SMILES | COc1ccc(NCc2ccc(cc2)C(=O)Nc2cc(ccc2O)-c2cccs2)cc1OC |
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| Structure | 
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