| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
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| Ligand | BDBM19414 |
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| Substrate/Competitor | BDBM19411 |
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| Meas. Tech. | HDAC Enzyme Activity Assay |
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| pH | 8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 80±n/a nM |
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| Citation |  Moradei, OM; Mallais, TC; Frechette, S; Paquin, I; Tessier, PE; Leit, SM; Fournel, M; Bonfils, C; Trachy-Bourget, MC; Liu, J; Yan, TP; Lu, AH; Rahil, J; Wang, J; Lefebvre, S; Li, Z; Vaisburg, AF; Besterman, JM Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem50:5543-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| BDBM19414 |
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| BDBM19411 |
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| Name | BDBM19414 |
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| Synonyms: | N-[2-amino-5-(thiophen-2-yl)phenyl]-4-{[(3,4-dimethoxyphenyl)amino]methyl}benzamide | benzamide-type inhibitor, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25N3O3S |
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| Mol. Mass. | 459.56 |
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| SMILES | COc1ccc(NCc2ccc(cc2)C(=O)Nc2cc(ccc2N)-c2cccs2)cc1OC |
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| Structure | 
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