Reaction Details |
| Report a problem with these data |
Target | Cathepsin S |
---|
Ligand | BDBM19514 |
---|
Substrate/Competitor | BDBM19490 |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
pH | 6.5±n/a |
---|
Temperature | 295.15±n/a K |
---|
IC50 | 0.2±n/a nM |
---|
Citation | Gauthier, JY; Black, WC; Courchesne, I; Cromlish, W; Desmarais, S; Houle, R; Lamontagne, S; Li, CS; Massé, F; McKay, DJ; Ouellet, M; Robichaud, J; Truchon, JF; Truong, VL; Wang, Q; Percival, MD The identification of potent, selective, and bioavailable cathepsin S inhibitors. Bioorg Med Chem Lett17:4929-33 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Cathepsin S |
---|
Name: | Cathepsin S |
Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
Type: | Protein |
Mol. Mass.: | 37507.38 |
Organism: | Homo sapiens (Human) |
Description: | P25774 |
Residue: | 331 |
Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
|
|
|
BDBM19514 |
---|
BDBM19490 |
---|
Name | BDBM19514 |
Synonyms: | (2R)-N-(1-cyanocyclopropyl)-3-[(3,4-dichlorobenzene)sulfonyl]-2-{[(1S)-2,2,2-trifluoro-1-phenylethyl]amino}propanamide | trifluoroethylamine inhibitor, 24 |
Type | Small organic molecule |
Emp. Form. | C21H18Cl2F3N3O3S |
Mol. Mass. | 520.352 |
SMILES | FC(F)(F)[C@@H](N[C@@H](CS(=O)(=O)c1ccc(Cl)c(Cl)c1)C(=O)NC1(CC1)C#N)c1ccccc1 |r| |
Structure |
|