Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM19529 |
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Substrate/Competitor | BDBM19480 |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | 0.3±n/a nM |
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Citation | Li, CS; Deschenes, D; Desmarais, S; Falgueyret, JP; Gauthier, JY; Kimmel, DB; Léger, S; Massé, F; McGrath, ME; McKay, DJ; Percival, MD; Riendeau, D; Rodan, SB; Thérien, M; Truong, VL; Wesolowski, G; Zamboni, R; Black, WC Identification of a potent and selective non-basic cathepsin K inhibitor. Bioorg Med Chem Lett16:1985-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_RABIT | CTSK |
Type: | Enzyme |
Mol. Mass.: | 36879.51 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | n/a |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
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BDBM19529 |
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BDBM19480 |
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Name | BDBM19529 |
Synonyms: | (2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-[4-(4-methylphenyl)phenyl]ethyl]amino}pentanamide | trifluoroethylamine analogue, 18 |
Type | Small organic molecule |
Emp. Form. | C23H26F3N3O |
Mol. Mass. | 417.4672 |
SMILES | CC(C)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(C)cc1)C(F)(F)F)C(=O)NCC#N |r| |
Structure |
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