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TargetCathepsin K
LigandBDBM19529
Substrate/CompetitorBDBM19480
Meas. Tech.Enzyme Inhibition Assay
IC50 0.3±n/a nM
Citation Li, CSDeschenes, DDesmarais, SFalgueyret, JPGauthier, JYKimmel, DBLéger, SMassé, FMcGrath, MEMcKay, DJPercival, MDRiendeau, DRodan, SBThérien, MTruong, VLWesolowski, GZamboni, RBlack, WC Identification of a potent and selective non-basic cathepsin K inhibitor. Bioorg Med Chem Lett16:1985-9 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CATK_RABIT | CTSK
Type:Enzyme
Mol. Mass.:36879.51
Organism:Oryctolagus cuniculus (rabbit)
Description:n/a
Residue:329
Sequence:
MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
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  Blast E-value cutoff:
BDBM19529
BDBM19480
NameBDBM19529
Synonyms:(2S)-N-(cyanomethyl)-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-[4-(4-methylphenyl)phenyl]ethyl]amino}pentanamide | trifluoroethylamine analogue, 18
TypeSmall organic molecule
Emp. Form.C23H26F3N3O
Mol. Mass.417.4672
SMILESCC(C)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(C)cc1)C(F)(F)F)C(=O)NCC#N |r|
Structure
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