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TargetTyrosine-protein kinase SYK
LigandBDBM243356
Substrate/Competitorn/a
Meas. Tech.In Vitro SYK Inhibition Assay
pH7.8±n/a
Temperature298.15±n/a K
IC50<500±n/a nM
Commentsextracted
Citation Benjahad, AMartin, JSchalon, CPez, DChevenier, ESandrinelli, FPicoul, WMoussy, A Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors US Patent US10053455 Publication Date 8/21/2018
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase SYK
Name:Tyrosine-protein kinase SYK
Synonyms:KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:Enzyme
Mol. Mass.:72079.99
Organism:Homo sapiens (Human)
Description:P43405
Residue:635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM243356
n/a
NameBDBM243356
Synonyms:5-{5-[3-(4-Methyl- pyrimidin-2-ylamino)- phenyl]-oxazol-2-yl}-5,8- diaza-spiro[3.5]nonan-9- one | US10053455, 012
TypeSmall organic molecule
Emp. Form.C21H22N6O2
Mol. Mass.390.4384
SMILESCc1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CCC2)n1
Structure
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