| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM243358 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro SYK Inhibition Assay |
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| pH | 7.8±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | >2000±n/a nM |
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| Comments | extracted |
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| Citation |  Benjahad, A; Martin, J; Schalon, C; Pez, D; Chevenier, E; Sandrinelli, F; Picoul, W; Moussy, A Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors US Patent US10053455 Publication Date 8/21/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
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| Type: | Enzyme |
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| Mol. Mass.: | 72079.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405 |
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| Residue: | 635 |
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| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM243358 |
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| n/a |
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| Name | BDBM243358 |
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| Synonyms: | 4-{5-[3-(4-Morpholin-4- yl-pyrimidin-2-ylamino)- phenyl]-oxazol-2-yl}-4,7- diaza-spiro[2.5]octan-8- one | US10053455, 014 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N7O3 |
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| Mol. Mass. | 447.4897 |
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| SMILES | O=C1NCCN(c2ncc(o2)-c2cccc(Nc3nccc(n3)N3CCOCC3)c2)C11CC1 |
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| Structure | 
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