Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM243360 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro SYK Inhibition Assay |
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pH | 7.8±n/a |
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Temperature | 298.15±n/a K |
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IC50 | <500±n/a nM |
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Comments | extracted |
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Citation | Benjahad, A; Martin, J; Schalon, C; Pez, D; Chevenier, E; Sandrinelli, F; Picoul, W; Moussy, A Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors US Patent US10053455 Publication Date 8/21/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM243360 |
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n/a |
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Name | BDBM243360 |
Synonyms: | 5-{5-[3-(4- Trifluoromethyl- pyrimidin-2-ylamino)- phenyl]-oxazol-2-yl}-5,8- diaza-spiro[3.5]nonan-9- one | US10053455, 016 |
Type | Small organic molecule |
Emp. Form. | C21H19F3N6O2 |
Mol. Mass. | 444.4098 |
SMILES | FC(F)(F)c1ccnc(Nc2cccc(c2)-c2cnc(o2)N2CCNC(=O)C22CCC2)n1 |
Structure |
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