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Reaction Details
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TargetCathepsin S
LigandBDBM19653
Substrate/CompetitorBDBM19546
Meas. Tech.Enzyme Inhibition Assay
pH5.5±n/a
Temperature310.15±n/a K
Ki 12±n/a nM
Citation Chatterjee, AKLiu, HTully, DCGuo, JEpple, RRusso, RWilliams, JRoberts, MTuntland, TChang, JGordon, PHollenbeck, TTumanut, CLi, JHarris, JL Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorg Med Chem Lett17:2899-903 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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  Blast E-value cutoff:
BDBM19653
BDBM19546
NameBDBM19653
Synonyms:(2R)-2-(cyclopentylmethyl)-4-(morpholin-4-yl)-4-oxo-N-[(2S)-1-{[4-(trifluoromethoxy)phenyl]amino}pentan-2-yl]butanamide | succinamide peptidomimetic, 19
TypeSmall organic molecule
Emp. Form.C26H38F3N3O4
Mol. Mass.513.5928
SMILESCCC[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCC1)CC(=O)N1CCOCC1 |r|
Structure
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