| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM19656 |
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| Substrate/Competitor | BDBM19546 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 5.5±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 20±n/a nM |
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| Citation |  Chatterjee, AK; Liu, H; Tully, DC; Guo, J; Epple, R; Russo, R; Williams, J; Roberts, M; Tuntland, T; Chang, J; Gordon, P; Hollenbeck, T; Tumanut, C; Li, J; Harris, JL Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorg Med Chem Lett17:2899-903 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
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| Type: | Protein |
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| Mol. Mass.: | 37507.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25774 |
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| Residue: | 331 |
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| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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| BDBM19656 |
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| BDBM19546 |
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| Name | BDBM19656 |
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| Synonyms: | (2R)-2-(2-cyclopentylethyl)-4-(morpholin-4-yl)-4-oxo-N-[(2S)-4-phenyl-1-{[4-(trifluoromethoxy)phenyl]amino}butan-2-yl]butanamide | succinamide peptidomimetic, 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H42F3N3O4 |
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| Mol. Mass. | 589.6888 |
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| SMILES | FC(F)(F)Oc1ccc(NC[C@H](CCc2ccccc2)NC(=O)[C@H](CCC2CCCC2)CC(=O)N2CCOCC2)cc1 |r| |
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| Structure | 
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