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TargetCathepsin K
LigandBDBM19780
Substrate/CompetitorBDBM19485
Meas. Tech.Enzyme Inhibition Assay
pH5.5±n/a
Temperature295.15±n/a K
Ki 1.4±n/a nM
Citation Yamashita, DSMarquis, RWXie, RNidamarthy, SDOh, HJJeong, JUErhard, KFWard, KWRoethke, TJSmith, BRCheng, HYGeng, XLin, FOffen, PHWang, BNevins, NHead, MSHaltiwanger, RCNarducci Sarjeant, AALiable-Sands, LMZhao, BSmith, WWJanson, CAGao, ETomaszek, TMcQueney, MJames, IEGress, CJZembryki, DLLark, MWVeber, DF Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. J Med Chem49:1597-612 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:Enzyme
Mol. Mass.:36975.68
Organism:Homo sapiens (Human)
Description:P43235
Residue:329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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  Blast E-value cutoff:
BDBM19780
BDBM19485
NameBDBM19780
Synonyms:(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4R,7R)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide | Azepan-3-one compound 12
TypeSmall organic molecule
Emp. Form.C27H32N4O6S
Mol. Mass.540.631
SMILESCC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1CC[C@@H](C)N(CC1=O)S(=O)(=O)c1ccccn1 |r|
Structure
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