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TargetCathepsin L1
LigandBDBM19770
Substrate/CompetitorBDBM19485
Meas. Tech.Enzyme Inhibition Assay
pH5.5±n/a
Temperature295.15±n/a K
Ki 0.04±n/a nM
Citation Yamashita DSMarquis RWXie RNidamarthy SDOh HJJeong JUErhard KFWard KWRoethke TJSmith BRCheng HYGeng XLin FOffen PHWang BNevins NHead MSHaltiwanger RCNarducci Sarjeant AALiable-Sands LMZhao BSmith WWJanson CAGao ETomaszek TMcQueney MJames IEGress CJZembryki DLLark MWVeber DF Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. J Med Chem 49:1597-612 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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  Blast E-value cutoff:
BDBM19770
BDBM19485
NameBDBM19770
Synonyms:(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4S,5S)-5-methyl-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide | Azepan-3-one compound 2
TypeSmall organic molecule
Emp. Form.C27H32N4O6S
Mol. Mass.540.631
SMILESCC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1[C@@H](C)CCN(CC1=O)S(=O)(=O)c1ccccn1 |r|
Structure
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