| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM19781 |
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| Substrate/Competitor | BDBM19485 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 5.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 3.9±n/a nM |
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| Citation |  Yamashita, DS; Marquis, RW; Xie, R; Nidamarthy, SD; Oh, HJ; Jeong, JU; Erhard, KF; Ward, KW; Roethke, TJ; Smith, BR; Cheng, HY; Geng, X; Lin, F; Offen, PH; Wang, B; Nevins, N; Head, MS; Haltiwanger, RC; Narducci Sarjeant, AA; Liable-Sands, LM; Zhao, B; Smith, WW; Janson, CA; Gao, E; Tomaszek, T; McQueney, M; James, IE; Gress, CJ; Zembryki, DL; Lark, MW; Veber, DF Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. J Med Chem49:1597-612 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM19781 |
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| BDBM19485 |
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| Name | BDBM19781 |
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| Synonyms: | (2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4R,7S)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide | Azepan-3-one compound 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32N4O6S |
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| Mol. Mass. | 540.631 |
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| SMILES | CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H]1CC[C@H](C)N(CC1=O)S(=O)(=O)c1ccccn1 |r| |
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| Structure | 
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