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TargetCathepsin V
LigandBDBM19769
Substrate/CompetitorBDBM19485
Meas. Tech.Enzyme Inhibition Assay
Ki 1.8±n/a nM
Citation Yamashita DSMarquis RWXie RNidamarthy SDOh HJJeong JUErhard KFWard KWRoethke TJSmith BRCheng HYGeng XLin FOffen PHWang BNevins NHead MSHaltiwanger RCNarducci Sarjeant AALiable-Sands LMZhao BSmith WWJanson CAGao ETomaszek TMcQueney MJames IEGress CJZembryki DLLark MWVeber DF Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. J Med Chem 49:1597-612 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin V
Name:Cathepsin V
Synonyms:Cathepsin (V and K) | Cathepsin U
Type:Enzyme
Mol. Mass.:37341.06
Organism:Homo sapiens (Human)
Description:O60911
Residue:334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM19769
BDBM19485
NameBDBM19769
Synonyms:(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4S)-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide | Azepan-3-one compound 1 | CHEMBL286364
TypeSmall organic molecule
Emp. Form.C26H30N4O6S
Mol. Mass.526.605
SMILESCC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CCCN(CC1=O)S(=O)(=O)c1ccccn1 |r|
Structure
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