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TargetCathepsin S
LigandBDBM19774
Substrate/CompetitorBDBM19485
Meas. Tech.Enzyme Inhibition Assay
Ki 350±n/a nM
Citation Yamashita, DSMarquis, RWXie, RNidamarthy, SDOh, HJJeong, JUErhard, KFWard, KWRoethke, TJSmith, BRCheng, HYGeng, XLin, FOffen, PHWang, BNevins, NHead, MSHaltiwanger, RCNarducci Sarjeant, AALiable-Sands, LMZhao, BSmith, WWJanson, CAGao, ETomaszek, TMcQueney, MJames, IEGress, CJZembryki, DLLark, MWVeber, DF Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors. J Med Chem49:1597-612 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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  Blast E-value cutoff:
BDBM19774
BDBM19485
NameBDBM19774
Synonyms:(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4S,6R)-6-methyl-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide | Azepan-3-one compound 6
TypeSmall organic molecule
Emp. Form.C27H32N4O6S
Mol. Mass.540.631
SMILESCC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1C[C@@H](C)CN(CC1=O)S(=O)(=O)c1ccccn1 |r|
Structure
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