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TargetCathepsin S
LigandBDBM19782
Substrate/CompetitorBDBM19490
Meas. Tech.Enzyme Inhibition Assay
IC50 20±n/a nM
Citation Barrett, DGCatalano, JGDeaton, DNLong, STMcFadyen, RBMiller, ABMiller, LRSamano, VTavares, FXWells-Knecht, KJWright, LLZhou, HQ Acyclic, orally bioavailable ketone-based cathepsin K inhibitors. Bioorg Med Chem Lett17:22-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM19782
BDBM19490
NameBDBM19782
Synonyms:(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(2S)-3-oxo-4-(pyridine-2-sulfonamido)butan-2-yl]pentanamide | CHEMBL31545 | ketone, 1
TypeSmall organic molecule
Emp. Form.C24H28N4O6S
Mol. Mass.500.567
SMILESCC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@@H](C)C(=O)CNS(=O)(=O)c1ccccn1 |r|
Structure
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